NANOTECHNOLOGY STRATEGY AS ANTIBACTERIAL: A PRIMER FOR THE NOTICE

Abstract

Multidrug-resistant (MDR) bacteria pose a major threat to all fields of medical science as it can result in treatment failure which can have severe consequences, especially in case of critical patients. The availability of new antibacterial agents appeared to be a very complex process. One of the most important aspect of modern field research is nanotechnology, it deals with synthesis, design and manipulation of particles structures ranging from approximately 1-100nm. Nanoparticles (NPs) are of great importance in areas like health care, cosmetics, food and feed, environmental health e.t.c. Nanoparticles matrix properties and constituent materials can be used to categorized them into inorganic and organic nanosystems. Techniques use within the synthesis of NPs includes; chemical, physical, chemistry, and biological methods, every methodology has its advantages and disadvantages with common issues of value, quantifiability and uniform particle size. Famous microbiologist Alexander Fleming said that “There is probably no chemotherapeutic drug to which in suitable circumstances the bacteria can not react by in some way acquiring fastness.” thus, there's high chance that the organism can also become resistance to newly developed medication at later stage. To this end NPs are considered to be good antibacterial agents and may overcome the barrier of MDR owing to their ability to anchor to the bacterial cell wall, multifunctional mechanisms to intervene normal cell functionality and subsequently penetrate it, thereby causing structural changes in the cell membrane permeability leading to cell death.