CRISPR-Cas SYSTEMS: A POTENTIAL TOOL TO REDUCE THE GLOBAL BURDEN OF ANTIMICROBIAL RESISTANCE

Authors

  • Mr. Yusuf Amuda Tajudeen University of Ilorin, Nigeria
  • Mr. Iyiola Olatunji Oladunjoye University of Ilorin, Nigeria
  • Dr. Habiba Iliyasu Atta Ahmadu Bello University, Zaria, Nigeria
  • Mr. Kehinde Eyitayo Oyediji University of Ilorin, Nigeria

DOI:

https://doi.org/10.36547/be.273

Keywords:

CRISPR-Cas, Antimicrobial Resistance, Antibiotics

Abstract

Antimicrobial resistance is one of the top global health threats driving our planet to the post-antibiotic era. The formulation of antibiotics is expensive and time-consuming, and this may have delayed the production of new ones. Therefore, approaches such as Clustered Regularly Interspersed Short Palindromic Repeats-associated protein-Cas—CRISPR-Cas, a system which is capable of reverting Antimicrobial Resistance Genes (ARGs) could be the potential means of significantly reducing the burden of antimicrobial resistance globally. In this perspective, we highlight how this system has been previously applied in vivo and in vitro studies to tackle antibiotics resistance, stating its relevance as well as challenges while providing recommendation for the effective use of this system.

Author Biographies

Mr. Yusuf Amuda Tajudeen, University of Ilorin, Nigeria

Department of Microbiology, Faculty of Life Sciences, Ilorin, Nigeria

Mr. Iyiola Olatunji Oladunjoye, University of Ilorin, Nigeria

Department of Microbiology, Faculty of Life Sciences, University of Ilorin, Nigeria.

Dr. Habiba Iliyasu Atta, Ahmadu Bello University, Zaria, Nigeria

Department of Microbiology, Faculty of Life Sciences, Ahmadu Bello University, Zaria, Nigeria. Senior lecturer.

Mr. Kehinde Eyitayo Oyediji, University of Ilorin, Nigeria

Department of Microbiology, Faculty of Life Sciences, University of Ilorin, Nigeria.

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Published

2021-04-13

How to Cite

Tajudeen, Y., Oladunjoye, I., Atta, H., & Oyediji, K. (2021). CRISPR-Cas SYSTEMS: A POTENTIAL TOOL TO REDUCE THE GLOBAL BURDEN OF ANTIMICROBIAL RESISTANCE. Bacterial Empire, 4(2), e273. https://doi.org/10.36547/be.273

Issue

Section

Bacteriology Articles