Does angiogenesis change in response to endocrine disrupting substances like bisphenols? - A review
DOI:
https://doi.org/10.36547/ae.2024.6.4.90-95Keywords:
Angiogenesis, Bisphenols, Endothelial cells, VEGFAbstract
The angiogenesis represents the formation of new blood vessels. Tissue angiogenesis requires the balance of several stimuli and inhibitors. From the point of view of several mechanisms involved in the formation of new blood vessels, this process is highly sensitive to the influence of chemicals affecting the immune and vascular systems. The main signaling mechanism that regulates the migration and proliferation of endothelial cells, which form the basis of any artery, is vascular endothelium growth factors (VEGF) and their receptors. The VEGF-dependent signaling pathway is necessary for the development of the embryonic vascular system. Since the scientific community has recently examined the impact of common endocrine disruptors, such as bisphenols, a theory on the potential influence of angiogenesis is put up regarding the exact mechanism of action of these compounds. A great advantage in investigating the influence of bisphenols on the vascular system and vascular formation is the use of model cell systems of the vessels endothelial lining.
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Copyright (c) 2025 Denis Bažány, Hana Greifová; Tomáš Jambor; Katarína Tokárová, Lucia Zuščíková, Norbert Lukáč

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